Intraocular lenses (IOLs) are artificial lenses which can be used for changing the pure lens of the attention. Mostly, they’re used to switch lenses which have been clouded by cataracts. Roughly 30 million cataract surgical procedures had been carried out worldwide in 2022.1 Yearly this quantity will increase as a result of growing prevalence of eye situations related to the growing old inhabitants, way of life modifications and different elements.
A number of forms of IOLs are used for cataract surgical procedure. Globally, cataracts are a serious contributor to visible impairment. In low and middle-income nations, cataracts are accountable for over 50% of blindness instances.2 The commonest IOL is the monofocal IOL, which permits for focus at a hard and fast distance. Different forms of IOLs, resembling multifocal and accommodative lenses, which permit the affected person to have totally different focusing powers inside the identical lens. Multifocal lenses have areas inside the lens that enable for viewing shut and distant objects. Accommodative lenses finest simulate the pure lens of the attention by profiting from the pure musculature of the attention to bodily change the refractive properties of the IOL.
As per the “World Intraocular Lens Market Worth, 2019-2029” chart, the multifocal IOL market compromised greater than half of the whole IOL market primarily based on the 2022 market worth.3 This development is anticipated to be noticed over the forecast interval, with the multifocal lens market gaining market shares annually. Regardless of this quick progress, multifocal IOL models composed not more than 15% of the whole IOL models bought in 2022 globally. This disparity is as a result of excessive common promoting value (ASP) of multifocal lenses.
In 2022, the ASP for multifocal IOLs had been virtually eight occasions increased in comparison with monofocal IOLs.3 It will stay one of many major elements limiting the excessive progress of multifocal IOL over the forecast interval, regardless of its quite a few benefits. This text will focus on the primary driving elements for the continued worldwide progress of IOL.
Ageing of the Inhabitants Driving IOL Market Progress
Worldwide progress in IOL will be primarily attributed to the growing old of the inhabitants. As international healthcare has improved, the common lifespan of the inhabitants has expanded. Whereas this can be a constructive end result, it additionally implies that people have a better probability of reaching an age the place they might encounter age-associated situations, resembling cataracts. Consequently, rise of an growing old inhabitants instantly correlates with the rising incidence fee of cataracts, together with the necessity to deal with it.
Frequent age-related eye situations embrace presbyopia, glaucoma, dry eyes, age-related muscular degeneration, cataracts and others. In keeping with the World Well being Group, at the least 2.2 billion folks have a close to or distance imaginative and prescient impairment with at the least 1 billion of those instances being preventable.4 The primary situation inflicting distance imaginative and prescient impairment or blindness are cataracts, which impacts round 95 million folks globally.4
Consequently, the necessity for reasonably priced and efficient therapy is crucial to scale back morbidity related to cataracts. Subsequently, firms need to be ready to reply to the growing demand for cataract surgical procedures.
Quite a few main rivals within the IOL market are benefiting from this market progress, in addition to some newer rivals which can be bringing novel know-how into the market. The primary rivals within the international IOL market are Alcon, J&J Imaginative and prescient Care, and Bausch & Lomb.
Elevated Incidence of Eye Circumstances
Globally, the prevalence variety of cataracts elevated by virtually 130% from 1990 to 2019.5 This may be attributed to a number of elements. One such issue is way of life modifications. Particularly, elevated display screen time and publicity to digital gadgets contribute to earlier onset of imaginative and prescient issues which boosts the demand for IOL. Digital eye pressure (DES) encompasses a spread of ocular signs which come up from extended utilization of digital digital gadgets.
The COVID-19 pandemic’s lockdown measures curtailed outside actions for folks of all ages, resulting in elevated display screen time. Based mostly on the statistics, the prevalence of DES signs in youngsters grew to 55%.6 Sure research point out that blue mild publicity emitted by digital screens might induce oxidative stress inside the lens of the attention, doubtlessly enjoying a job within the improvement of cataracts. Oxidative stress arises when there may be an imbalance between the manufacturing of reactive oxygen species (ROS) and the physique’s capability to counteract them. This type of oxidative harm is assumed to contribute to a spread of eye-related situations, together with the formation of cataracts.7 You will need to observe that there’s nonetheless quite a lot of debate on this matter as some research counsel that elements apart from ultraviolet (UV) mild publicity would possibly play a extra important position.
Prevalence of Diabetes
In 2021, each 1 in 10 adults was residing with diabetes, which accounts for greater than 520 million folks.8 By 2045, this quantity is predicted to succeed in 782 million in line with the Worldwide Diabetes Federation.8 People with diabetes have a notably elevated danger, starting from 2 to five time increased, of growing cataracts, which frequently manifest at an earlier stage of their lives.
There are a number of organic mechanisms that contribute to the elevated danger of growing cataracts. Mostly, elevated ranges of blood sugar in diabetes provoke a phenomenon often known as glycation, whereby surplus sugar molecules bind to proteins inside the lens of the attention.9 This interplay ends in a change of the construction and performance of lens proteins, inducing a cloudy and fewer clear look. This opacity subsequently triggers the event of cataracts. Subsequently, the growing prevalence of diabetes considerably impacts cataract surgical procedures.
Intraocular Lenses Analysis and Improvement
Because the demand for IOL rises annually, there are quite a few medical analysis research aiming at bettering the know-how. A selected space of analysis facilities on enhancing biocompatibility, attaining improved visible high quality and adjustability, minimizing surgical incisions and mitigating issues resembling posterior capsular opacification and ophthalmitis.10
Moreover, quite a lot of medical analysis goals at advancing optics. This encompasses the creation of multifocal and accommodative IOLs, which permits people to realize readability of imaginative and prescient throughout totally different distances with out counting on eyeglasses. The customization of IOL is one other analysis space investigating personalised IOLs to cater to the distinct visible necessities of every affected person, thereby optimizing their imaginative and prescient after surgical procedure. Furthermore, ongoing research are delving into IOLs which will be modified after being implanted, permitting for exact changes to refine the affected person’s visible acuity.11
Closing Factors
The worldwide intraocular lens market has been evolving and rising dramatically prior to now, and it’s anticipated to take care of progress because the wants of the inhabitants enhance. With the excessive price of most biomaterials, North America and Western Europe symbolize the best share of the whole market. Moreso, IOLs are slowly turning into extra prevalent throughout the globe. Alcon stays the main firm out there worldwide.
For additional insights and extra granular market knowledge, please see the report Ophthalmic System Market Dimension, Share, and Tendencies Evaluation – World – 2023-2029 by iData Analysis.
Concerning the Authors
Kateryna Hronska is a senior analysis analyst at iData Analysis. She works on analysis initiatives concerning the medical system trade, publishing the World Diagnostic and Interventional Ophthalmic System analysis report.
Kamran Zamanian, Ph.D., is CEO and founding associate of iData Analysis. He has spent over 20 years working out there analysis trade with a dedication to the research of medical gadgets used within the well being of sufferers everywhere in the globe.
About iData Analysis
For 19 years, iData Analysis has been a powerful advocate for data-driven decision-making inside the international medical system, dental, and pharmaceutical industries. By offering customized analysis and consulting options, iData empowers its purchasers to belief the supply of knowledge and make essential strategic selections with confidence.
Citations
- Basaldua, B. (2023, March 3). The Way forward for Cataract Surgical procedure. iOR Companions | Workplace-Based mostly Surgical procedure.
- Tognetto, D., & Giglio, R. (2021, October 1). Synthetic Intelligence Purposes and cataract administration: A scientific evaluation. Survey of Ophthalmology.
- iData Analysis Inc. World Diagnostic and Interventional Ophthalmic System Market – 2023. Printed ___ 2023. Accessed ___, 2023.
- World Well being Group. (n.d.). Vision Impairment and blindness. World Well being Group.
- Fang, R., Yu, Y.-F., Li, E.-J., Lv, N.-X., Liu, Z.-C., Zhou, H.-G., & Track, X.-D. (2022, November 12). World, regional, nationwide burden and gender disparity of cataract: Findings from the worldwide burden of illness research 2019 – BMC public well being. BioMed Central.
- Kaur, Okay., Gurnani, B., & Nayak, S. (2022, October). Digital Eye strain- A complete evaluation. Ophthalmology and remedy.
- Nita, M., & Grzybowski, A. (2016). The position of the reactive oxygen species and oxidative stress within the pathomechanism of the age-related ocular illnesses and different pathologies of the anterior and posterior eye segments in adults. Oxidative drugs and mobile longevity.
- Diabetes all over the world in 2021. IDF Diabetes Atlas. (n.d.).
- Kiziltoprak, H., Tekin, Okay., & Inanc, M. (2019, March 15). Cataract in diabetes mellitus. World journal of diabetes.
- Luo, C., Wang, H., & Chen, X. (2022, Might 23). Current advances of intraocular lens supplies and floor modification in cataract surgical procedure. Frontiers.
- Salerno, L. C., Tiveron, M. C., & Alió, J. L. (2017). Multifocal intraocular lenses: Sorts, outcomes, issues and easy methods to clear up them. Taiwan journal of ophthalmology.
